Auriane destrument elucidating the role of mkk4 in neuronal apoptosis

06-Feb-2016 09:23 by 10 Comments

Auriane destrument elucidating the role of mkk4 in neuronal apoptosis - pregnant after dating for two months

Our research has focused on developing advanced separation methods, accurate and structurally informative mass spectrometry techniques and automated informatics tools that now make rapid throughput profiling of glycans possible.These methods are used to determine the role of glycans in diseases allowing us to observe and characterize the glycan signatures of cancer and autoimmune diseases in tissues and in blood.

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To advance our knowledge, I have developed two novel models of neuronal apoptosis using primary cultures of cortical neurones (MECN) and cerebellar granule neurones (CGN) in which MKK4 expression can be deleted.

The absence of MKK4 significantly impedes stress-induced caspase-3 activation in both cell types and partially protects neurones against stress-induced death and apoptosis.

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Furthermore, the loss of MKK4 leads to the inhibition of JNK3 activation following stress, and causes a marked decrease in the expression of c-Jun, a major target of JNK.

The research group is currently focused on the glycomic and glycomic proteomic analysis of milk.

They have recently characterized the free oligosaccharides in mammalian milk including human, bovine, procine, murine, and several primate species. Lebrilla is a Distinguished Professor at the University of California, Davis in the Department of Chemistry and Biochemistry and Molecular Medicine in the School of Medicine. He was an Alexander von Humboldt Fellow and a NSF-NATO Fellow at the Technical University in Berlin.In the brain, apoptosis is triggered by the activation of the c-Jun N-terminal protein kinase (JNK) signalling pathway by two mitogen-activated protein kinases (MAPKs): MKK4 and MKK7. While both proteins activate JNK in response to various extracellular stimuli, the biological functions of MKK4 and MKK7 in neuronal cell death remain to be identified. In the brain, apoptosis is triggered by the activation of the c-Jun N-terminal protein kinase (JNK) signalling pathway by two mitogen-activated protein kinases (MAPKs): MKK4 and MKK7.While both proteins activate JNK in response to various extracellular stimuli, the biological functions of MKK4 and MKK7 in neuronal cell death remain to be identified.To advance our knowledge, I have developed two novel models of neuronal apoptosis using primary cultures of cortical neurones (MECN) and cerebellar granule neurones (CGN) in which MKK4 expression can be deleted.